A plea to provide best evidence in trials under sample-size restrictions: the example of pioglitazone to resolve leukoplakia and erythroplakia in Fanconi anemia patients

Abstract In planning a clinical trial for demonstrating the efficacy 3 piece horse wall art of pioglitazone to resolve leukoplakia and erythroplakia in Fanconi anemia patients we had to discuss the need for a randomized controlled trial particularly under sample-size restrictions as very promising results were available from a single-arm clinical t

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Rumpel Leede Phenomenon: Once in a Blue Moon Sign

Rumpel Leede sign(RL sign) is characterized by the presence of a petechial 3 piece horse wall art rash that results from acute dermal capillary rupture.It was documented in literature quite often and it is associated with conditions like hypertension, diabetes, chronic steroid use, secondary to autoimmune disorders, mechanical trauma, thrombocytope

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Semi-rational design and modification of phosphoketolase to improve the yield of tyrosol in Saccharomyces cerevisiae

Tyrosol is an important component of pharmaceuticals, nutraceuticals, and cosmetics, and their biosynthetic pathways are currently a hot research topic.d-Erythrose 4-phosphate is a key precursor for the biosynthesis of tyrosol in Saccharomyces cerevisiae.Hence, the flux of d-Erythrose 4-phosphate determined the yield of tyrosol synthesis.In this st

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